20174-689樓動物房健康監測結果如下:

一、病毒(抗體)

1. Pneumonia virus

0/22

0/14

2. Rat Reo Virus 

0/14

3. Mouse Adenovirus (FL/K86) Ab

0/22

4. Lymphocytic choriomeningitis virus (LCMV)

0/22

5. Mouse (CARB)

0/22

6. Minute virus of mice (MVM)

1/22

7. Mouse hepatitis virus (MHV)

0/22

8. Mouse parvovirus (MPV)

0/22

9. Sialodacryoadenitis virus (SDAV)

0/14

10. Mycoplasma pulmonis (M. pul)

0/22

0/14

11. Encephalitozoon cuniculi (sporozoan) Ab

0/14

12.Murine Norovirus (MNV)

0/22

13. Hantaan virus

0/22

14. Kilham rat virus (KRV)

0/14

15. Rat Theilovirus

0/14

 

二、細菌

小鼠

大鼠

1.      Helicobacter spp.PCR

3/24

2/15

2.      Bordetella bronchiseptica

0/25

0/15

3.      Salmonella spp

0/25

0/15

 

二、寄生蟲

1. Spironucleus spp

0/24

0/15

2.Giardia spp

0/24

0/15

3. Trichomonads

0/24

0/15

4.Entamoeba spp

0/24

0/15

5. PinwormSyphacia spp.- cellophane tape

0/24

0/15

6.Flea

0/24

0/15

7.Louse

0/24

0/15

8Mite

0/24

0/15

實驗動物中心

 

陽性動物疾病簡介(見下頁)

 

1.Helicobacter

                                                                                                                              

Helicobacter (H.) species (spp.) are Gram-negative, microaerophilic, spiral-to-curve-shaped bacteria with sheathed flagella. The pathogenic potential of the murine Helicobacter spp. is unclear. H. muridarum may occasionally colonize the stomach  and elicit gastritis. H. hepaticus and H. bilis are associated with chronic, active hepatitis ; Koch's postulates have been fulfilled for the association of H. hepaticus with hepatitis. H. hepaticus may also induce liver tumors (both adenomas and carcinomas) in older male A/JCr mice and inflammatory large bowel disease in severe combined immunodeficiency (scid/scid) and nude (Hfh11nu/Hfh11nu) mice. Various mouse strains were reported to differ greatly in susceptibility to H. hepaticus-induced liver disease with A/JCr and scid/scid mice being highly susceptible and C57BL/6NCr mice being resistant . Male mice were more severely affected than females. The earliest histopathologic liver lesions seen, at 2 to 6 months of age, were focal necrosis and focal non-suppurative inflammation. By 6 to 10 months of age, extensive liver involvement included hepatocytomegaly, bile ductular (oval cell) hyperplasia, and cholangitis.

 

4.Minute virus of mice (MVM)Mouse parvovirus (MPV)
Clinical signs and lesions Mouse parvoviral infections does not cause clinical symptoms , even in immunodeficient animals. Mouse parvovirus (MVM) is in addition to the self-limiting infection 4 weeks after infection immunocompetent animals . MVM appear to be more pathogenic for hematopoietic cells than  the mouse parvoviruses(MPVs). The MPVs cause no histological lesions

(摘自 Charles River technical sheet

 

 

實驗動物中心

201771