Biobank	Cancer Research Laboratory
Division of Pharmacology and Toxicology	Division of Research Resource
Division of Cellular and Immune Therapy
Genomics and Proteomics Medical Laboratory
Division of Medical Statistics and Bioinformatics

Division of Pharmacology and Toxicology
About us
Due to the limitation of space and personnel, nowadays, our division cooperates strongly with the Division of Toxicology, Department of Laboratory Medicine.

Members

• Chief: Chu-Sung Hu M.D.
  Email:stephenhu30@hotmail.com
• Technician: Hsin-Yi Wu, Ph.D.
  Email:1020047@mail.kmuh.org.tw

Equipment

• GC mass

• LC tandem mass

• Atomic absorption spectrometry

Studied projects

1. Simultaneous determination of arecholine, arecaidine and metabolites in sailva, blood and urine by using liquid chromatography tandem mass spectrometry.
2. Blood, tissue levels of chloro-ethanol in rat by liquid chromatography tandem mass spectrometry.
3. Urinary phthalates levels of pregnant women
   by using liquid chromatography tandem mass spectrometry.

Publication (since 2012)

1. Lee CH, Lee KW, Fang FM, Wu DC, Tsai SM, Chen PH, Shieh TY, Chen CH, Wu IC, Huang HL, Chen BH, Chang CH, Chen MK, Chou SH, Tsai YS, Chiang SL, Warnakulasuriya S, Ko YC*. The neoplastic impact of tobacco-free betel-quid on the histological type and the anatomical site of aerodigestive tract cancers. Int J Cancer. 2012 ;131(5): E733-43.
2. Wu MT, Wu CF, Wu JR, Chen BH, Chen EK, Chao MC, Liu CK, HO CK. The public health threat of phthalate-tainted foodstuffs in Taiwan: The policies the government implemented and the lessons we learned. Environ Int. 2012; 44:75-9.
3. Liu CC, Wu CF, Shiea J, Cho YT, Chou YH, Chen BH, Chien CY, Huang SP, Wu WJ, Shen JT, Chang MY, Huang CH, Chang AW, Wu MT. Detaection of melamine in a human renal uric acid stone by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) Clin Chim Acta. 2012; 413: 1689-95.
4. Wu MT, Chen BH, et al. A crossover study of noodle soup consumption in melamine-made bowls and total melamine excretion in urine. Arch Intern Med 2013(In press).
5. Lee HH, Lee JF, Lin SY, YY, Wu CF, Wu MT, Chen BH* Simultaneous quantification of urine flunitrazepam, nimetazepam and nitrazepam by using liquid chromatography tandem mass spectrometry. Clin Chim Acta. 2012 Oct 17.
6. Lin YT, Tsai MT, Chen YL, Cheng CM, Hung CC, Wu CF, Liu CC, Hsieh TJ, Shiea J, Chen BH, Wu MT. Can melamine levels in 1-spot ovenight urine specimens predict the total previous 24-hour melamine excretion levels in school children? Clin Chim Acta. 2013; 420:128-33.
7. Wu MT, Wu CF, Chen BH, Chen EK, Chen YL, Shiea JT, Lee WT; Chao MC, Wu JR. Intake of phthalate-tainted foods alters thyroid functions in Taiwanese children". PLOS ONE 2013;8(1):e55005. .
8. Wu CF, Chen BH, Shiea J, Chen EK, Liu CK, Chao MC, Ho CK, Wu JR, Wu MT. Temporal changes of urinary oxidative metabolites of di(2-ethylhexyl)phthalate after the 2011. phthalate incident in Taiwanese children: findings of a six month follow-up. Environ Sci Technol. 2013; 3;47:13754-62.
9. Lin CC, Huang HH, Hu CW, Chen BH, Chong IW, Chao YY, Huang YL. Trace elements, oxidative stress and glycemic control in young people with type 1 diabetes mellitus. J Trace Elem Med Biol. 2014;28:18-22.

Future plan

1. To provide advanced toxicology laboratory service for the pharmacokinetic study, such as imatinib, everonimus concentrations.
2. To elevate the research standard through the traditional basic research, mixed clinical medicine.
3. Hopefully to have more our toxicology laboratory space and instruments for research.