▊1.新冠病毒研究：透過我們的BSL-3實驗室分離定序新冠病毒變異株，包括來自感染COVID-19的患者的野生型、Alpha、Delta 和 Omicron 變異株。並分析這些病毒變種和相關的流行病學數據及治療策略

● Tsai JJ*, Chiou SS, Chen PC, Chen CH, Lin PC , Tsai CY, Chuang LW, Hwang SJ, Chong IW, Liu LT. The epidemiology and phylogenetic trends of Omicron subvariants from BA.5 to XBB.1 in Taiwan. J Infect Public Health. 2024 Nov;17(11):102556. SCI IF 4.7. PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH 40/403 (Q1).
[ Download ]

● Liu LT, Tsai JJ*. Unveiling COVID-19 Treatment Strategies for Immunocompromised Individuals: Therapeutic Innovations and Latest Findings. Int J Rheum Dis. 2024;27:e14900. doi: 10.1111/1756-185X.14900. SCI IF 2.5. RHEUMATOLOGY 24/34 (Q3).
[ Download ]

●Yang CR, Chang SY, Gong YN, Huang CG, Tung TH, Liu W, Chan TC, Hung KS, Shang HS, Tsai JJ, Kao CL, Wu HL, Liu LY, Lin WY, Fan YC, King CC*, Ku CC*. The emergence and successful elimination of SARS-CoV-2 dominant strains with increasing epidemic potential in Taiwan’s 2021 outbreak. Heliyon 2023 Dec (9) e22436. https://doi.org/10.1016/j.heliyon.2023.e22436. SCI IF 4.0 MULTIDISCIPLINARY SCIENCES 23/73 (Q2).
[ Download ]

●Liu LT, Chiou SS, Chen PC, Chen CH, Lin PC, Tsai CY, Chuang WL, Hwang SJ, Chong IW, Tsai JJ*. Epidemiology and analysis of SARS-CoV-2 Omicron subvariants BA.1 and 2 in Taiwan. Sci Rep. 2023 Oct 3;13(1):16583. doi: 10.1038/s41598-023-43357-7.SCI IF 4.6. MULTIDISCIPLINARY SCIENCES 22/73 (Q2).
[ Download ]

●Dai YC, Lin YC, Ching LL, Tsai JJ, Ishikawa K, Tsai WY, Chen JJ, Nerurkar VR, Wang WK*. Determining the time of booster dose based on the half-life and neutralization titers against SARS-CoV-2 variants of concern in fully vaccinated individuals. Microbiol Spectr. 2023 Jul 10:e0408122. doi: 10.1128/spectrum.04081-22. SCI IF 3.7. MICROBIOLOGY 62/135 (Q2).
[ Download ]

●Tsai JJ, Liu LT, Chen CH, Chen LJ, Wang SI, James CC Wei*. COVID-19 outcomes in patients with rheumatoid arthritis with biologic or targeted synthetic DMARDs. RMD Open. 2023 Jul;9(3):e003038. doi: 10.1136/rmdopen-2023-003038. SCI IF 6.2. RHEUMATOLOGY 6/34 (Q1).
[ Download ]

●Liu LT, Tsai JJ*, Chu JH, Chen CH, Chen LJ, Lin PC, Tsai CY, Hsu MC, Chuang WL, Hwang SJ, Chong IW. The identification and phylogenetic analysis of SARS-CoV-2 delta variants in Taiwan. Kaohsiung J Med Sci. 2023 Jun;39(6):624-636. doi: 10.1002/kjm2.12665. SCI IF 3.3. MEDICINE, RESEARCH & EXPERIMENTAL 81/136 (Q3).
[ Download ]

●Liu LT, Tsai JJ *, Chang K, Chen CH, Lin PC, Tsai CY, Tsai YY, Hsu MC, Chuang WL, Chang JM, Hwang SJ, Chong IW. Identification and Analysis of SARS-CoV-2 Alpha Variants in the Largest Taiwan COVID-19 Outbreak in 2021.Front Med (Lausanne). 2022 Apr 25;9: 869818. SCI IF 5.058. MEDICINE, GENERAL & INTERNAL 52/172 (Q2).
[ Download ]

●Liu LT, Tsai JJ *, Chen CH, Lin PC, Tsai CY, Tsai YY, Hsu MC, Chuang WL, Chang JM, Hwang SJ, Chong IW. Isolation and Identification of a Rare Spike Gene Double-Deletion SARS-CoV-2 Variant From the Patient With High Cycle Threshold Value. Front Med (Lausanne). 2022 Jan 6;8: 822633. SCI IF 5.058. MEDICINE, GENERAL & INTERNAL 52/172 (Q2).
[ Download ]

▊2.我們開發並使用了各種RT-PCR 系統和快速診斷測試，以檢測台灣南部、索羅門群島發燒患者的急性樣本和蚊子中的登革病毒感染並與國家衛生研究院團隊合作檢測蚊子中的登革病毒，同時比較快篩試劑性能。我們也與早稻田大學伊藤教授合作，研發超高敏感性與特異性的Thio-NAD cycling based Enzyme-Linked Immunosorbent Assay (Ultra-sensitive ELISA)方法來檢驗臨床檢體中的登革病毒。

●Chen PK, Chang JH, Ke LY, Kao JK, Chen CH, Yang RC, Yoshimura T, Ito E*, Tsai JJ*. Advanced Detection Method for Dengue NS1 Protein Using Ultrasensitive ELISA with Thio-NAD Cycling. Viruses. 2023 Sep 8;15(9):1894. doi: 10.3390/v15091894. SCI IF 4.7. VIROLOGY 15/36 (Q2).
[ Download ]

●Liu LT, Chen CH, Lin PC, Tsai CY, Hsu MC, Huang BY, Tsai YY, Tsai JJ*. Evaluation of a new NS1 rapid diagnostic test using a single acute‐phase serum panel collected during the largest dengue outbreak in Taiwan history in 2015. Kaohsiung J Med Sci. 2022 Apr;38(4):385-389. SCI IF 2.996. MEDICINE, RESEARCH & EXPERIMENTAL 97/139 (Q3).
[ Download ]

●Cheng L, Liu WL, Tsou YT, Li JC, Chien CH, Su MP, Liu KL, Huang YL, Wu SC, Tsai JJ, Hsieh SL*, Chen CH*. Transgenic Expression of Human C-Type Lectin Protein CLEC18A Reduces Dengue Virus Type 2 Infectivity in Aedes aegypti. Front Immunol. 2021 Mar 9;12:640367. doi: 10.3389/fimmu.2021.640367. eCollection 2021. SCI IF 7.561. IMMUNOLOGY 24/162 (Q1.)
[ Download ]

●Cheng L, Liu WL, Li HH, Su MP, Wu SC, Chen HW, Pan CY, Tsai JJ*, Chen CH*. Releasing Intracellular NS1 from Mosquito Cells for the Detection of Dengue Virus-Infected Mosquitoes. Viruses. 2020 Sep 29;12(10):1105. SCI IF 3.816. VIROLOGY 12/37 (Q2).
[ Download ]

●Liu LT, Chen CH, Tsai CY, Lin PC, Hsu MC, Huang BY, Wang YH, Tsai JJ*. Evaluation of rapid diagnostic tests to detect dengue virus infections in Taiwan. PLoS One. 2020 Sep 29;15(9):e0239710. SCI IF 2.74. MULTIDISCIPLINARY SCIENCES 27/71 (Q2).
[ Download ]

​●Tsai JJ*, Liu WL, Lin PC, Huang BY, Tsai CY, Lee PA, Tsai YL, Chou PH, Chung S, Liu LT, Chen CH. A fully automated sample-to-answer PCR system for easy and sensitive detection of dengue virus in human serum and mosquitos. PLoS One. 2019 Jul 10;14(7):e0218139. SCI IF 2.766. MULTIDISCIPLINARY SCIENCES 24/69 (Q1).
[ Download ]

●Tsai JJ*, Liu WL, Lin PC, Huang BY, Tsai CY, Chou PH, Lee FC, Ping CF, Lee PA, Liu LT, Chen CH. An RT-PCR panel for rapid serotyping of dengue virus serotypes 1 to 4 in human serum and mosquito on a field-deployable PCR system. PLoS One. 2019 Mar 25;14(3):e0214328. SCI IF 2.766. MULTIDISCIPLINARY SCIENCES 24/69 (Q2).
[ Download ]

●Liu LT, Dalipanda T, Jagilly R, Wang YH, Lin PC, Tsai CY, Lai WT, Tsai JJ*. Comparison of two rapid diagnostic tests during a large dengue virus serotype 3 outbreak in the Solomon Islands in 2013. PLoS One. 2018 Aug 10;13(8):e0202304. SCI IF 2.766. MULTIDISCIPLINARY SCIENCES 15/64 (Q1).
[ Download ]

●Tsai JJ*, Liu LT, Lin PC, Tsai CY, Chou PH, Tsai YL, Chang HG, Lee PA. Validation of the Pockit Dengue Virus Reagent Set for Rapid Detection of Dengue Virus in Human Serum on a Field-Deployable PCR System. J Clin Microbiol. 2018 Apr 25;56(5):e01865-17. doi: 10.1128/JCM.01865-17. SCI IF 4.054. MICROBIOLOGY 31/127 (Q1)
[ Download ]

▊3.與台南國立成功大學的彭貴春教授合作對急性感染期的病毒和宿主免疫反應進行了分析。證實在登革病毒感染期間的急性血漿樣本中造血幹細胞和原始細胞的活動、登革熱嚴重程度的細胞因子特徵以及感染性囊泡。

●Puc I, Ho TC, Chien YW, Tan SS, Fong YC, Chen YJ, Wang SH, Li YH, Chen CH, Chen PL, Perng GC, Tsai JJ*. Mobilization of hematopoietic stem and progenitor cells during dengue virus infection. Int J Mol Sci. 2022 Nov 18;23(22):14330. SCI IF 6.208. BIOCHEMISTRY & MOLECULAR BIOLOGY 69/196 (Q1).
[ Download ]

●Puc I, Ho TC, Yen KL, Vats A, Tsai JJ, Chen PL, Chien YW, Lo YC*, Perng GC*. Cytokine Signature of Dengue Patients at Different Severity of the Disease. Int J Mol Sci. 2021 Mar 12;22(6):2879. SCI IF 5.924. BIOCHEMISTRY & MOLECULAR BIOLOGY 67/295 (Q1).
[ Download ]

●Hsu AY, Wu SR, Tsai JJ, Chen PL, Chen YP, Chen TY, Lo YC, Ho TC, Lee M, Chen MT, Chiu YC*, Perng GC. Infectious dengue vesicles derived from CD61+ cells in acute patient plasma exhibited a diaphanous appearance. Sci Rep. 2015 Dec 11;5: 17990. SCI IF 5.578. MULTIDISCIPLINARY SCIENCES 5/57 (Q1).
[ Download ]

●Tsai JJ, Chokephaibulkit K, Chen PC, Liu LT, Hsiao HM, Lo YC, Perng GC*. Role of cognitive parameters in dengue hemorrhagic fever and dengue shock syndrome. JOURNAL OF BIOMEDICAL SCIENCE.2013 Dec .2013; 20(1): 88. SCI IF 2.458 MEDICINE, RESEARCH & EXPERIMENTAL 57/121 (Q2).
[ Download ]

●Tsai JJ, Liu LT, Chang Ko, Wang SH, Hsiao HM, Clark KB, Perng GC*. The importance of hematopoietic progenitor cells in dengue. Ther Adv Hematol. 2012 Feb;3(1):59-71.
[ Download ]

●Tsai JJ, Jen YH, Chang JS, Hsiao HM, Norsakran S, Perng GC*. Frequency alterations in key innate immune cell components in peripheral blood of dengue patients detected by FACS analysis. J Innate Immunuty 2011;3(5):530-40. Epub 2011 Feb 18. SCI IF 4.458. IMMUNOLOGY 32/137 (Q1).
[ Download ]

▊4.與夏威夷大學的王維恭教授合作，研究了登革病毒感染後的多克隆抗體和單克隆抗體

●Hsieh SC, Tsai WY, Tsai JJ, Stone M, Simmons G, Busch MP, Lanteri M, Stramer SL, Balmaseda A, Harris E, Wang WK*. Identification of Anti-Premembrane Antibody as a Serocomplex-Specific Marker To Discriminate Zika, Dengue, and West Nile Virus Infections. J Virol. 2021 Sep 9;95(19): e0061921. SCI IF 5.103. VIROLOGY 9/37 (Q1).
[ Download ]

●Tsai WY, Chen HL, Tsai JJ, Dejnirattisai W, Jumnainsong A, Mongkolsapaya J, Screaton G, Crowe JE Jr, Wang WK*. Potent Neutralizing Human Monoclonal Antibodies Preferentially Target Mature Dengue Virus Particles: Implication for Novel Strategy for Dengue Vaccine. J Virol. 2018 Nov 12;92(23): e00556-18. SCI IF 4.36. VIROLOGY 8/35 (Q1).
[ Download ]

●Tsai WY, Durbin A, Tsai JJ, Hsieh SC, Whitehead S, Wang WK*. Complexity of Neutralizing Antibodies against Multiple Dengue Virus Serotypes after Heterotypic Immunization and Secondary Infection Revealed by In-Depth Analysis of Cross-Reactive Antibodies. J Virol. 2015 Jul;89(14):7348-62. SCI IF 4.439. VIROLOGY 7/33 (Q1).
[ Download ]

●HE, Tsai WY, Liu IJ, Li PC, Liao MY, Tsai JJ, Wu YC, Lai CY, Lu CH, Huang JH, Chang GJ, Wu HC, Wang WK*. Analysis of epitopes on dengue virus envelope protein recognized by monoclonal antibodies and polyclonal human sera by a high throughput assay. PLoS Negl Trop Dis. 2012 Jan;6(1):e1447 (1-12). SCI IF 4.716. TROPICAL MEDICINE 1/21 (Q1).
[ Download ]

▊5.在第二次世界大戰以來最大規模的登革熱爆發之後，我們調查了台灣南部大都市高雄的登革熱病毒血清陽性率。同時也比較登革病毒不同檢測原理的ELISA方法在血清陽性率研究中的性能。

●Tsai JJ, Tsai CY, Lin PC, Chen CH, Tsai WY, Dai YC, Lin YC, Celia Pedroso, Carlos Brites, Wang WC*. Comparing the performance of dengue virus IgG and IgG-capture enzyme-linked immunosorbent assays in seroprevalence study. BMC Infectious Diseases. 2023 May 8;23(1):301. doi: 10.1186/s12879-023-08307-8. SCI IF 3.669. INFECTIOUS DISEASES 60/95 (Q3).
[ Download ]

●Tsai JJ, Lin PC, Tsai CY, Wang YH, Liu LT*. Low frequency of asymptomatic dengue virus-infected donors in blood donor centers during the largest dengue outbreak in Taiwan. PLoS One. 2018 Oct 8;13(10): e0205248. SCI IF 2.766. MULTIDISCIPLINARY SCIENCES 15/64 (Q1).
[ Download ]

●Tsai JJ, Liu CK*, Tsai WY, Liu LT, Tyson J, Tsai CY, Lin PC, Wang WK*. Seroprevalence of dengue virus in two districts of Kaohsiung City after the largest dengue outbreak in Taiwan since World War II. PLoS Negl Trop Dis. 2018 Oct 24;12(10): e0006879. SCI IF 4.367. TROPICAL MEDICINE 1/20 (Q1).
[ Download ]

▊6.自2016年茲卡病毒爆發以來，我們與夏威夷大學的王維恭教授合作開發了不同的血清學測試來區分登革病毒、茲卡病毒和其他黃病毒。這些包括以NS1為基礎的ELISA、MIA及以VLP為基礎的ELISA和西方墨點法分析。

●Chen GH, Dai YC, Hsieh SC, Tsai JJ, Sy AK, Jiz M, Pedroso C, Brites C, Netto EM, Kanki PJ, Saunders DRD, Vanlandingham DL, Higgs S, Huang YS, Wang WK*. Detection of anti-premembrane antibody as a specific marker of four flavivirus serocomplexes and its application to serosurveillance in endemic regions. EMERGING MICROBES & INFECTIONS. 2024 Dec;13(1):2301666. SCI IF 13.2. IMMUNOLOGY 13/161 (Q1).
[ Download ]

●Tsai WY, Driesse K, Tsai JJ, Hsieh SC, Sznajder Granat R, Jenkins O, Chang GJ, Wang WK*. Enzyme-linked immunosorbent assays using virus-like particles containing mutations of conserved residues on envelope protein can distinguish three flavivirus infections. Emerg Microbes Infect. 2020 Dec;9(1):1722-1732. SCI IF 5.776. IMMUNOLOGY 30/159 (Q1).
[ Download ]

●Tyson J, Tsai WY, Tsai JJ, Mässgård L, Stramer SL, Lehrer AT, Nerurkar VR, Wang WK*. A high-throughput and multiplex microsphere immunoassay based on non-structural protein 1 can discriminate three flavivirus infections. PLoS Negl Trop Dis. 2019 Aug 23;13(8):e0007649. SCI IF 4.487. PARASITOLOGY 5/37 (Q1).
[ Download ]

●Tyson J, Tsai WY, Tsai JJ, Brites C, Mässgård L, Ha Youn H, Pedroso C, Drexler JF, Stramer SL, Balmaseda A, Harris E, Wang WK*. Combination of Nonstructural Protein 1-Based Enzyme-Linked Immunosorbent Assays Can Detect and Distinguish Various Dengue Virus and Zika Virus Infections. J Clin Microbiol. 2019 Jan 30;57(2):e01464-18. SCI IF 4.959. MICROBIOLOGY 24/133 (Q1).
[ Download ]

●Tsai WY, Youn HH, Tyson J, Brites C, Tsai JJ, Pedroso C, Drexler JF, Balmaseda A, Harris E, Wang WK*. Use of Urea Wash ELISA to Distinguish Zika and Dengue Virus Infections. Emerg Infect Dis. 2018 Jul;24(7):1355-1359. SCI IF 7.422. INFECTIOUS DISEASES 4/88 (Q1)
[ Download ]

●Tsai WY, Youn HH, Brites C, Tsai JJ, Tyson J, Pedroso C, Drexler JF, Stone M, Simmons G, Busch MP, Lanteri M, Stramer SL, Balmaseda A, Harris E, Wang WK*. Distinguishing Secondary Dengue Virus Infection From Zika Virus Infection With Previous Dengue by a Combination of 3 Simple Serological Tests. Clin Infect Dis. 2017 Nov 13;65(11):1829-1836. SCI IF 8.216. INFECTIOUS DISEASES 4/84 (Q1)
[ Download ]

▊7.其他關於登革熱疫苗及登革熱重症、併發症之治療及登革病毒基因相關研究

​●HC Wang, CC Lin, CH Chang, JJ Tsai* Case report: dengue fever associated acute macular neuroretinopathy. Front Med (Lausanne).2024 Mar 22:11:1379429. SCI IF 3.9. MEDICINE, GENERAL & INTERNAL 58/169 (Q2).
[ Download ]

​●Tsai JJ, Chang K, Chen CH, Liao CL, Chen LJ, Tsai YY, Tsai CY, Lin PC, Hsu MC, Liu LT*. Dengue virus serotype did not contribute to clinical severity or mortality in Taiwan's largest dengue outbreak in 2015. Eur J Med Res. 2023 Nov 6;28(1):482. doi: 10.1186/s40001-023-01454-3. SCI IF 4.2. MEDICINE, RESEARCH & EXPERIMENTAL 63/136 (Q2).
[ Download ]

​●Dai YC, Sy AK, Jiz M, Tsai JJ, Bato J, Quinoñes MA, Reyes Mary AJ, Wang WK * Identification of prior dengue-naïve Dengvaxia recipients with an increased risk for symptomaticdengue during fever surveillance in Philippines. Frontiers in Immunology, section Viral Immunology. 2023 SCI IF 7.3. IMMUNOLOGY 35/161 (Q1).
[ Download ]

●Tsai JJ*, Hsieh MH, Liu LT, Hsiao HM, Perng GC. Case report mortality from septic shock in a dengue infected patient. Southeast Asian J Trop Med Public Health 2013 July;44(4):623-629. SCI IF 0.773. Tropical Medicine 16/19 (Q4).
[ Download ]

●Chu PY, Ke GM, Chen PC, Liu LT, Tsai YC, Tsai JJ *. Spatiotemporal dynamics and epistatic interaction sites in dengue virus type 1: a comprehensive sequence-based analysis. PLoS One. 2013 Sep.;8(9): e74165. doi:10.1371. SCI IF 3.73. MULTIDISCIPLINARY SCIENCES 7/56 (Q1).
[ Download ]

●Tsai JJ*, Chen PC, Liu LT, Chang K, Yao JH, Hsiao HM, Clark KB, Chen YH, Hsu Alan YH, Perng GC*. Pathogenic parameters derived from activated platelets in dengue patients. Trop Med Surg 2013 Sep;1(5): 1-7.
[ Download ]

●Clark KB, Hsiao HM, Noisakran S, Tsai JJ, Perng GC*. Role of microparticles in dengue virus infection and its impact on medical intervention strategies. Yale J Biol Med. 2012 Mar;85(1):3-18.
[ Download ]

●Chan KS, Chang JS, Chang K, Lin CC, Huang JH, Lin WR, Chen TC, Hsieh HC, Lin SH, Lin JC, Lu PL, Chen YH, Lin CY, Tsai JJ*. Effect of serotypes on clinical manifestations of dengue fever in adults. J Microbiol Immunol Infect. 2009 Dec;42(6):471-8. SCI IF 1.631. MICROBIOLOGY 82/116 (Q3).
[ Download ]

●Chang K, Lu PL, Ko WC, Tsai JJ, Tsai WH, Chen CD, Chen YH, Chen TC, Hsieh HC, Pan CY, Harn MR*. Dengue fever scoring system: new strategy for the early detection of acute dengue virus infection in Taiwan. J Formos Med Assoc. 2009 Nov;108(11):879-85. SCI IF 1.125. MEDICINE, GENERAL & INTERNAL 76/153 (Q2).
[ Download ]

​●Chen TC, Lu PL, Chen YH, Tsai JJ*, Chen TP. Dengue hemorrhagic fever complicated with acute idiopathic scrotal edema and polyneuropathy. Am J Trop Med Hyg. 2008 Jan;78(1):8-10. SCI IF 2.446. TROPICAL MEDICINE 5/19 (Q2).
[ Download ]

●Kuo MC, Lu PL, Chang JM, Lin MY, Tsai JJ, Chen YH, Chang K, Chen HC, Hwang SJ*. Impact of renal failure on the outcome of dengue viral infection. Clin J Am Soc Nephrol. 2008 Sep;3(5):1350-6. Epub 2008 Jul 30. SCI IF 4.763. UROLOGY & NEPHROLOGY 6/69 (Q1).
[ Download ]

▊8.進行其他有關抗生素、中草藥萃取物、淋巴癌、風濕病、皮肌炎與其他感染症等相關研究/span>

●Wang PY, Wang CY, Sung WY, Ou TT, Wu CC, Tseng CC, Chen PP, Ho HY, Tsai JJ, Yen JH*. Characterize the Taiwanese idiopathic inflammatory myositis cohort by hierarchical clustering. Formosan Journal of Rheumatology 2024 June 38(1):40-52.
[ Download ]

●Lin RJ, Chung C, Wang CY, Wang PY, Sung WY, Tsai JJ. The cutaneous manifestation of dermatomyositis confounded with allergic rash might defer the diagnosis of malignancy. Int J Rheum Dis.2024 Jan;27(1):e14945. doi: 10.1111/1756-185X.14945. SCI IF 2.5. RHEUMATOLOGY 24/34 (Q3).
[ Download ]

●Wang CY, Lee, HC, Lin RJ, Tsai, JJ*. Spondyloarthritis and nonbacterial thrombotic endocarditis as paraneoplastic manifestations in treatment-naive Burkitt lymphoma. International Journal of Rheumatic Diseases. 2023 March 20. doi:10.1111/1756-185X.14651. SCI IF 2.5. International Journal of Rheumatic Diseases 24/34 (Q3).
[ Download ]

●Wang CY, Lee HC, Lin RJ, Tsai JJ*. Nonbacterial thrombotic endocarditis as a paraneoplastic manifestation of newly diagnosed splenic large B cell lymphoma. The Kaohsiung Journal of Medical Sciences. 2023 Mar 23. doi:10.1002/kjm2.12677. SCI IF 2.996. MEDICINE, RESEARCH & EXPERIMENTAL 97/139 (Q3).
[ Download ]

●Wang CH, Yang CC, Hsu WT, Qian F, Ding J, Wu HP, Tsai JJ, Yang CJ, Su MY, Chen SC, Lee CC*. Optimal initial antibiotic regimen for the treatment of acute appendicitis: a systematic review and network meta-analysis with surgical intervention as the common comparator. J Antimicrob Chemother. 2021 Jun 18;76(7):1666-1675. SCI IF 5.79. INFECTIOUS DISEASES 14/93 (Q1).
[ Download ]

●Chang K, Lee NY, Ko WC, Lin WR, Chen YH, Tsai JJ, Chen TC, Lin CY, Chang YT, Lu PL*. Characteristics of scrub typhus, murine typhus, and Q fever among elderly patients: Prolonged prothrombin time as a predictor for severity. J Microbiol Immunol Infect. 2019 Feb;52(1):54-61. SCI IF 2.455. MICROBIOLOGY 84/133 (Q3).
[ Download ]

●Chang K, Lin WR, Chen PC, Tsai JJ *. Regression of Kaposi's sarcoma after anti-Tuberculous therapy in a HIV-negative case with disseminated. Tuberculosis Biomedical Journal of Scientific & Technical Research.2018 May. 4(4), pages 4048-4050.
[ Download ]

●Cheng YC, Huang CH, Lin WR, Lu PL, Chang K, Tsai JJ, Bojang KS, Lin CY, Chen YH*. Clinical outcomes of septic patients with diabetic ketoacidosis between 2004 and 2013 in a tertiary hospital in Taiwan. J Microbiol Immunol Infect. 2014 Nov 4. pii: S1684-1182(14)00187-X. doi: 10.1016/j.jmii.2014.08.018. (SCI).
[ Download ]

●Lin TJ, Yeh CF, Wang KC, Chiang LC, Tsai JJ, Chang JS*. Water extract of Pueraria lobata Ohwi has anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines. Kaohsiung J Med Sci. 2013 Dec;29(12):651-7. doi: 10.1016/j.kjms.2013.06.001. Epub 2013 Aug 12. SCI IF 0.502. Medicine, Research & Experimental 104/121 (Q4).
[ Download ]

●林淑惠(Shu-Hui Lin);陳惇杰(Tun-Chieh Chen);盧柏樑(Po-Liang Lu);蔡季君(Jih-Jin Tsai);林俊祐(Chun-Yu Lin);洪靖慈(Ching-Tzu Hung);林蔚如(Wei-Ru Lin);陳彥旭(Yen-Hsu Chen). 門診上呼吸道感染抗生素使用及介入措施成效評估. 感染控制雜誌 ，Vol.20 No.1 (20100201)： 1-12.
[ Download ]

●Kuo CY, Lin CY, Chen TC, Lin WR, Lu PL, Tsai JJ, Chang K, Hsieh HC, Chen Y-H*. Clinical features and prognostic factors in emphysematous urinary tract infection. J Microbiol Immunol Infect 2009 Oct; 42(5):393-400. SCI IF 1.116. MICROBIOLOGY 85/107 (Q4).
[ Download ]

●Su FM, Chang JS, Wang KC, Tsai JJ, Chiang LC*. A water extract of Pueraria lobata inhibited cytotoxicity of Enterovirus 71 in human foreskin fibroblast cell line. Kaohsiung J Med Sci. 2008 Oct; 24(10):523-30. SCI IF 0.474. MEDICINE, RESEARCH & EXPERIMENTAL 92/106 (Q4).
[ Download ]

●Teparrakkul P, Tsai JJ, Chierakul W, Gerstenmaier JF, Wacharaprechasgu T, Piyaphanee W, Limmathurotsakul D, Chaowagul W, Day NP, Peacock SJ*. Rheumatological manifestations in patients with melioidosis. Southeast Asian J Trop Med Public Health 2008; July, 39(4):649-655.
[ Download ]

▊9.愛滋病及毒癮患者治療及共同感染疾病調查

●Lee CY, Wu PH, Tsai JJ, Chen TC, Chang K, Lu PL*. Cascade Analysis of Anonymous Voluntary HIV Counseling and Testing Among Patients with HIV Infection in Taiwan. AIDS Patient Care STDS. 2020 Jul;34(7):303-315. SCI IF 3.795. PUBLIC,
[ Download ]

●Lee CY, Tseng YT, Lin WR, Chen YH, Tsai JJ, Wang WH, Lu PL *, Tsai HC*. AIDS-related opportunistic illnesses and early initiation of HIV care remain critical in the contemporary HAART era: a retrospective cohort study in Taiwan. BMC Infect Dis. 2018;18(1):352. SCI IF 2.62. INFECTIOUS DISEASES 44/88 (Q2).
[ Download ]

​●Hsieh MH, Wang SC, Hsieh MY, Huang CF, Yeh ML, Yang JF, Chang K, Lin WR, Lin CY, Chen TC, Huang JF, Dai CY, Tsai JJ, Chuang WL, Yu ML*. Hepatitis D virus infections among injecting drug users with and without human immunodeficiency virus infection in Taiwan. 2016 Oct Kaohsiung J Med Sci. (2016) 32, 526e530. SCI IF 1. MEDICINE, RESEARCH & EXPERIMENTAL 104/124 (Q4).
[ Download ]

●Lin HC, Wang PW, Yang YH, Tsai JJ, Yen CF*. Incarcerated intravenous heroin users: Predictors of post-release utilization of methadone maintenance treatment. JOURNAL OF ADDICTIVE DISEASES. 2016 May. 2016, VOL. 35, NO. 2, 109–118 SCI IF 1.781. SUBSTANCE ABUSE 18/34 (Q3).
[ Download ]

●Hsieh MH, Hsieh MY, Huang CF, Yeh ML, Wang SC, Yang JF, Chang K, Lin WR, Lin CY, Chen TC, Huang JF, Dai CY, Tsai JJ*, Chuang WL, Yu ML. Anti-HIV seropositivity was related to HBsAg seropositivity among injecting drug users in Taiwan. KAOHSIUNG JOURNAL OF MEDICAL SCIENCES. 2016 Feb. (2016) 32, 96e102. SCI IF 1. MEDICINE, RESEARCH & EXPERIMENTAL 104/124 (Q4).
[ Download ]

●Hieh MH, Lu PL, Kuo MC, Lin WR, Lin Cy, Lai CC, Tsai JJ, Chen TC, Huang SJ, Chen YH*. Prevalence of and associated factors with chronic kidney disease in human immunodeficiency virus-infected patients in Taiwan. J Microbiol Immunol Infect. 2015 Jun;48(3):256-262. SCI IF 2.349. MICROBIOLOGY 69/119 (Q3).
[ Download ]

●Yang CH, Chen KJ, Tsai JJ, Lin YH, Cheng SH, Wang KF, Chiou HY*. The impact of HAART initiation timing on HIV-TB co-infected patients, a retrospective cohort study. BMC Infect Dis. 2014 Jun 4;14:304. doi: 10.1186/1471-2334-14-304. SCI IF 2.561. INFECTIOUS DISEASES 35/72 (Q2).
[ Download ]

●Hsieh MH, Tsai JJ, Hsieh MY, Huang CF, Yeh ML, Yang JF, Chang K, Lin WR, Lin CY, Chen TC, Huang JF, Dai CY, Yu ML, Chuang WL*. Hepatitis C virus infection among injection drug users with and without human immunodeficiency virus co-infection. PLoS One. 2014 Apr 10;9(4):e94791. doi: 10.1371/journal.pone.0094791. eCollection 2014. SCI IF 3.534. MULTIDISCIPLINARY SCIENCES 8/55 (Q1).
[ Download ]

●Yen CF, Tsai JJ*, Wang PW, Yeh YC, Liu SC, Wang SH, Wang CC*. Unfavorable Attitudes Toward Receiving Methadone Maintenance Therapy and Associated Factors among Inmates Using Intravenous Heroin. Kaohsiung J Med Sci. 2011 Jan;27(1):25-31. Epub 2011 Jan 26. SCI IF 0.502. MEDICINE, RESEARCH & EXPERIMENTAL 104/121 (Q4).
[ Download ]

●Sun HY, Lee HC, Liu CE, Yang CL, Su SC, Ko WC, Lin CY, Tsai JJ, Wong WW, Ho MW, Cheng SH, Lin YH, Miao WJ, Hung*. Factors associated with isolated anti-hepatitis B core antibody in HIV-positive patients: impact of compromised immunity. J Viral Hepat. 17(8):578-587, 2010. SCI IF 3.502. GASTROENTEROLOGY & HEPATOLOGY 19/71 (Q2).
[ Download ]

●Sun HY, Ko WC, Tsai JJ, Lee HC, Wong WW, Su SC, Liu CE, Ho MW, Cheng SH, Yang CH, Sheng WH, Hung CC*. Seroprevalence of chronic hepatitis B virus infection among Taiwanese human immunodeficiency virus type 1-infected persons in the era of nationwide hepatitis B vaccination. Am J Gastroenterol. 2009 Apr;104(4):877-84. SCI IF 6.882. GASTROENTEROLOGY & HEPATOLOGY 5/71 (Q1).
[ Download ]

●Yu JK, Tok TS, Tsai JJ, Chang WS, Dzimadzi RK, Yen PH, Makombe SD, Nkhata A, Schouten EJ, Kamoto K, Harries AD*. What happens to patients on antiretroviral therapy who transfer out to another facility? PLoS ONE 2008 Apr 30;3(4):e2065, P.1-3. SCI IF 4.411. BIOLOGY 12/85 (Q1).
[ Download ]

▊10.斑疹傷寒、Q熱、瘧疾、屈公病等蟲媒或人畜共通傳染病相關研究

●Chang K, Lee NY, Ko WC, Tsai JJ, Lin WR, Chen TC, Lu PL, Chen YH*. Identification of factors for physicians to facilitate early differential diagnosis of scrub typhus, murine typhus, and Q fever from dengue fever in Taiwan. J Microbiol Immunol Infect. 2017 Feb;50(1):104-111. doi: 10.1016/j.jmii.2014.12.001. Epub 2014 Dec 26. SCI IF 2.973. INFECTIOUS DISEASES 50/125 (Q2).
[ Download ]

●Chang K, Chen YH, Lee NY, Lee HC, Lin CY, Tsai JJ, Lu PL, Chen TC, Hsieh HC, Lin WR, Lai PC, Chang CM, Wu CJ, Lai CH, Ko WC*. Murine typhus in southern Taiwan during 1992-2009. Am J Trop Med Hyg. 2012 Jul;87(1):141-7. SCI IF 2.592. TROPICAL MEDICINE 5/21 (Q1).
[ Download ]

●Chang K, Hsieh HC, Tsai JJ, Lin WR, Lu PL, Chen YH*. Diagnosis and management of imported Chikungunya fever in Taiwan: a case report. Kaohsiung J Med Sci. 2010 May;26(5):256-60. SCI IF 0.474. MEDICINE, RESEARCH & EXPERIMENTAL 92/106 (Q4).
[ Download ]

●張科;蔡季君;陳彥旭. 地方性斑疹傷寒. 感染控制雜誌 ，Vol.19 No.2 (20090401)：109-114.
[ Download ]

●Er TK, Chen PC, Tsai JJ*: Value of Liu’s stain in rapid diagnosis of Plasmodium ovale infection. Am J Emerg Med 2009; 27, 759.e3–759.e5. SCI IF 1.994. EMERGENCY MEDICINE 7/23 (Q2).
[ Download ]

●Tsai KH, Lu HY, Tsai JJ, Yu SK, Huang JH, Shu PY*. Human case of Rickettsia felis infection in Taiwan. Emerg Infect Dis 2008; Dec.,14(12):1970-2. SCI IF 6.859. INFECTIOUS DISEASES 3/58 (Q1).
[ Download ]

1.Tsai JJ*, Liu WL, Lin PC, Huang BY, Tsai CY, Chou PH, Lee FC, Ping CF, Lee PA, Liu LT, Chen CH. An RT-PCR panel for rapid serotyping of dengue virus serotypes 1 to 4 in human serum and mosquito on a field-deployable PCR system. ASTMH (American Society of Tropical Medicine & Hygiene) 68rd annual meeting; New Orleans, USA, 2019.11.20-11.24

2.Tsai JJ*, Liu LT, Lin PC, Tsai CY, Chou PH., Tsai YL, Chang HF, Lee PY. Field Deployable PCR System for rapid detection of dengue virus infection. ASTMH (American Society of Tropical Medicine & Hygiene) 67rd annual meeting; New Orleans, USA, 2018/10/28-11/1

3.Tsai JJ, Chang JS, Chang K, Chen PC, Liu LT, Ho TC, Tan SS, Chien YW, Lo YC, Perng GC. Transient Monocytosis Subjugates Low Platelet Count in Adult Dengue Patients. ASTMH (American Society of Tropical Medicine & Hygiene) 66rd annual meeting; Baltimore, USA, 2017/11/5-9

4.Tsai JJ*, Liu LT, Perng GC, Chien YW, Yang CY. Screening of dengue fever in the blood donors during the dengue outbreak in 2015 in southern Taiwan. ASTMH (American Society of Tropical Medicine & Hygiene) 65rd annual meeting; Atlanta, USA ,2016/11/11-17

5.Tsai WJ, Tsai JJ, Durbin A, Whitehead S, Wang WK*. Study of cross reactive antibodies against dengue virus envelope protein following heterotypic immunization and secondary infection. ASTMH (American Society of Tropical Medicine & Hygiene) 63rd annual meeting; New Orleans, USA, 2014/11/2-6. (Poster)
6.Tsai JJ. Dengue outbreak in Solomon Islands. 4th International Conference on the Control of Dengue Virus Infection: Pathogenesis and Clinical Aspects. Kaohsiung, Taiwan, 2014/10/27. (Oral speaker)

7.Chang K. Clinical Management of DHF/DSS and severe dengue. 4th International Conference on the Control of Dengue Virus Infection: Pathogenesis and Clinical Aspects. Kaohsiung, Taiwan, 2014/10/27. (Oral speaker)

8.Tsai JJ, Dalipanda T, Ross L, Manimu G, Chen PC, Liu LT, Lin WR, Hsiao SH, Perng GC, Yu ML, Lai WT. The evaluation of rapid diagnostic tests for dengue infections. ASTMH 62nd annual meeting; Washinton DC, USA, 2013/11/13-17. (Poster)

9.Tsai JJ, Chen PC, Liu LT, Chang K, Hsiao HM, Clark KB, Perng GC*. Parameters associated with activated platelets in dengue patients. ASTMH 61st annual meeting; Atlanta, USA, 2012/11/11-15. (Poster)

10.Tsai JJ*, Liu CH, Szutu CH, Cheng YJ, Kuo BY, Chang YL, Phunky D, Norsang T, Hu SH, Hsiao SH, Lai WT, Sheu SH. Pilot survey of health issues among Tibetan refugees in Mundgod, South Indian Tibetan Settlement. 60th ASTMH annual meeting; Philadelphia, USA, 2011/12/4-8. (Poster)

11.Tsai JJ*, Hsiao SH, Chen PC, Tenneth Dalipanda, James Auto, Chang Ko, Liu LT, Wang SH, Tsai YC, Lai WT, Sheu SH. The seroprevalence of dengue fever in Solomon Islands. 60th ASTMH annual meeting; Philadelphia, USA, 2011/12/4-8. (Poster)

12.Tsai JJ*, Hsiao SH, Dalipanda T, Auto J, Lai WT, Sheu SH. Prevalence of intestinal parasitic infections in Solomon Islands. 60th ASTMH annual meeting; Philadelphia, USA, 2011/12/4-8. (Poster)

13.Tsai JJ, Chang JS, Liu LT, Jen YH, Chang Ko, Hsiao HM, Perng GC*. The importance of platelet-derived microvesicles in dengue pathogenesis 60th ASTMH annual meeting; Philadelphia, USA, 2011/12/4-8. (Poster)

14.Wang WK*, Lin HE, Tsai WY, Liu IJ, Li PC, Liao MY, Tsai JJ, Wu YC, Lai CY, Lu CH, Chang GJ, Wu HC. Analysis and identification of epitopes on dengue virus envelope protein. 60th ASTMH annual meeting; Philadelphia, USA, 2011/12/4-8. (Oral Speaker)

15.Tsai JJ, Jen YH, Chang JS, Hsiao HM, Norsakran S, Perng GC*. Frequency alterations in key innate immune cell components in peripheral blood of dengue patients detected by FACS analysis. 59th ASTMH Annual Meeting, Atlanta, USA. 2010/11/3-7. (Poster)

16.Liu LT, Hung CH, Tsai JJ*. Potential Role of Monocyte in Dengue Virus Pathogenesis. 3nd International Symposium on Human Dengue Pathogenesis and Clinical Aspects in Kaohsiung, Taiwan. 2010/10/22-23. (Oral Speaker)

17.Liu LT, Tsai JJ*. Comparative analysis of full genomic sequences among different genotypes of dengue virus type 1. 2nd International Symposium on Human Dengue Pathogenesis and Clinical Aspects in Kaohsiung, Taiwan. 2009/10/30-31. (Oral Speaker)

18.Liu LT, Tsai JJ*. Investigation of Signaling Pathways Involved in Dengue Virus-induced TNFα Expression in THP-1 Cells. 2nd International Symposium on Human Dengue Pathogenesis and Clinical Aspects in Kaohsiung, Taiwan. 2009/10/30-31. (Oral Speaker)

19.郭昶宏, 王韋力, 朱育德, 李敏生, 蔡季君, 洪志興*. Effects of Dengue Virus on the Expression of Cytokines in Human Monocytes. 臺灣兒科醫學會第200屆學術演講會.臺中市, 2009/11/14-15.

20.林淑惠,陳惇杰*,蔡季君,盧柏樑,林蔚如,陳彥旭.門診上呼吸道感染抗生素使用及介入措施成效評估. 台灣感染症醫學會第七屆第三次會員大會與學術討論會.台北市, 2008/1/12-13.